The association between the age and the rate of tau accumulation and spreading in different sexes
Aβ drives faster tau accumulation and this effect is particularly strong at younger age and even further pronounced in men, whose tau epicenters are more densely interconnected with the rest of the brain. Together, age and sex have clear modulating effects on tau spreading, and heterogeneous AD trajectories may be partly arisen due to sex-specific differences in brain network architecture.
Authors
- Amir Dehsarvi (ORCID: https://orcid.org/0000-0001-7116-9741)
- Michael Ewers (ORCID: https://orcid.org/0000-0003-1856-9337)
- Anna Dewenter (ORCID: https://orcid.org/0000-0002-5636-196X)
- Anna Steward (ORCID: https://orcid.org/0000-0002-8438-3760)
- Fabian Wagner (ORCID: https://orcid.org/0000-0002-3088-0702)
- Matthias Brendel (ORCID: https://orcid.org/0000-0002-9247-2843)
- Sebastian Niclas Roemer (ORCID: https://orcid.org/0000-0003-3423-457X)
- Zeyu Zhu (ORCID: https://orcid.org/0000-0003-0970-4832)
- Nicolai Franzmeier (ORCID: https://orcid.org/0000-0001-9736-2283)
- Mattes Groß
Institutions
- German Center for Neurodegenerative Diseases (DE)
- LMU Klinikum (DE)
- Munich Cluster for Systems Neurology (DE)
- Ludwig-Maximilians-Universität München (DE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.090713
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00