Elevated amyloid‐ß and tau burden is associated with accelerated cognitive decline on a digital clock drawing test in preclinical AD
Our results suggest that longitudinal decline in DCTclock performance, especially in information processing or executive function, is related to early Aß/tau burden in older CN adults. Diminished longitudinal DCTclock performance, especially in latency features uniquely captured by digital tools, may reflect greater cognitive efforts in preclinical AD.
Authors
- Reisa A. Sperling (ORCID: https://orcid.org/0000-0003-1535-6133)
- Roos J. Jutten (ORCID: https://orcid.org/0000-0002-3712-4790)
- Keith A. Johnson (ORCID: https://orcid.org/0000-0002-4685-5173)
- Dana L. Penney (ORCID: https://orcid.org/0000-0003-3105-6974)
- Brian C. Healy (ORCID: https://orcid.org/0000-0001-5272-2425)
- Jessie Fanglu Fu (ORCID: https://orcid.org/0000-0002-4970-7811)
- Talia L. Robinson (ORCID: https://orcid.org/0000-0002-5655-8324)
- Julie C. Price
- Dorene M. Rentz (ORCID: https://orcid.org/0000-0002-6318-9213)
- Emma G. Thibault (ORCID: https://orcid.org/0000-0002-7873-742X)
- Marina Álvarez Alonso
- Randall Davis
- Grace A Del Carmen Montenegro
- Adela Francis Malave
Institutions
- Harvard University (US)
- Gordon Center for Medical Imaging (US)
- Massachusetts General Hospital (US)
- Lahey Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089175
- Citations
- 4
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.54