Histofluorescence analysis of Pittsburgh Compound B labeled pathology in Down syndrome putamen and frontal cortex
Striatal cyano-PiB load in putamen was not greater than in the frontal cortex layers II-IV in people with DS above the age of 42 years. The partial overlap of cyano-PiB labeled amyloid plaques with Aβ immunoreactive plaques suggests that only a subset of Aβ plaques were detected with cyano-PiB. Further characterization of cyano-PiB loads in deep layers of the frontal cortex as well as in DS cases at younger ages is warranted.
Authors
- Julia Kofler (ORCID: https://orcid.org/0000-0003-4298-7328)
- Miloš D. Ikonomović (ORCID: https://orcid.org/0000-0002-8745-3293)
- Jeremy P. Rouanet (ORCID: https://orcid.org/0000-0002-1800-9690)
- Alice Fung (ORCID: https://orcid.org/0000-0001-8939-6125)
- Kim Chan Ngo
- Florence Lai (ORCID: https://orcid.org/0000-0003-4354-0624)
- Elizabeth Head (ORCID: https://orcid.org/0000-0003-1115-6396)
- Elizabeth J. Andrews (ORCID: https://orcid.org/0000-0003-2463-5708)
- Jesse R. Pascual (ORCID: https://orcid.org/0000-0002-3307-0887)
- Tamara M Shamas
- Sierra Wright
- Michael Phelan
- Brenna Phelan
- Phong Ngo
Institutions
- Harvard University (US)
- University of Pittsburgh (US)
- University of California, Irvine (US)
- Massachusetts General Hospital (US)
- VA Pittsburgh Healthcare System (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091764
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00