Bi‐phasic Microtubule Defects in Tauopathy: Treatment Implications
We conclude that the biphasic changes in tau pathology with the subsequent MT defects may underlie the progressive neurodegeneration in tauopathy. Thus, therapies to correct tau and MT abnormalities in tauopathy must be vetted for the specific stages of the disease.
Authors
- Celeste M M. Karch (ORCID: https://orcid.org/0000-0002-6854-5547)
- Peter W. Baas (ORCID: https://orcid.org/0000-0002-1272-4538)
- Liang Qiang (ORCID: https://orcid.org/0000-0001-9896-602X)
- Xiaohuan Sun (ORCID: https://orcid.org/0009-0007-0165-2747)
Institutions
- Drexel University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089658
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00