Five‐year Trajectory of Mild Behavioral Impairment in People with Subjective Cognitive Complaints

To our knowledge this is largest study of trajectories of MBI symptoms. We show that symptoms are not stable but show an exponential increase over time in those with SCC, while in those with normal cognition the overall trend was flat. These are population averaged estimates and there will be a degree of variability in the data which may warrant more individual-level prediction modelling in future. As well as being a marker of cognitive risk, SCC may also represent a risk state for worsening neuropsychiatric symptoms.