The Nature of Episodic Memory Decline in Preclinical Alzheimer’s Disease
Subtle decline in episodic memory is evident during the preclinical phase of AD, affecting both delayed recall and recognition consistent with medial temporal lobe dysfunction. In addition, greater preclinical memory decline is associated with higher levels of an AD biomarker in CSF. Further research will determine if these memory changes can serve as a cognitive marker of preclinical AD.
Authors
- Mark A. Johnson (ORCID: https://orcid.org/0000-0002-8508-2724)
- Guerry M. Peavy (ORCID: https://orcid.org/0000-0001-7785-7916)
- Diane M. Jacobs (ORCID: https://orcid.org/0000-0003-0886-6784)
- Mark W. Bondi (ORCID: https://orcid.org/0000-0002-1742-3451)
- Douglas R Galasko (ORCID: https://orcid.org/0000-0001-6195-3241)
- Dean C. Delis
- Tamar H. Gollan (ORCID: https://orcid.org/0000-0003-4933-2594)
- David P. Salmon (ORCID: https://orcid.org/0000-0003-4533-4090)
- Kelsey R. Thomas (ORCID: https://orcid.org/0000-0003-4277-8876)
- A. Sharma (ORCID: https://orcid.org/0000-0001-5776-7817)
Institutions
- San Diego State University (US)
- University of California San Diego (US)
- VA San Diego Healthcare System (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.093414
- Citations
- 2
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.77