Apathy and fatigue, but not depression, associated with inflammatory biomarkers in older adults
In older persons, apathy and fatigue were differentially linked with inflammatory biomarkers, whereas previous associations between inflammation and depression were not replicated. Findings confirm the importance of fatigue, and provide novel insight into apathy, as prevalent and impairing symptoms which map to peripheral inflammation in older adults. Inflammation may at least partially underly the complex associations between apathy, depression and poorer health outcomes including dementia.
Authors
- Julian Norman Trollor (ORCID: https://orcid.org/0000-0002-7685-2977)
- Moyra E. Mortby (ORCID: https://orcid.org/0000-0002-9568-6628)
- Adam J. Guastella (ORCID: https://orcid.org/0000-0001-8178-4625)
- Henry Brodaty (ORCID: https://orcid.org/0000-0001-9487-6617)
- Fleur Harrison (ORCID: https://orcid.org/0000-0002-3432-7955)
- Karen A. Mather (ORCID: https://orcid.org/0000-0003-4143-8941)
- Perminder Singh Sachdev (ORCID: https://orcid.org/0000-0002-9595-3220)
Institutions
- The University of Sydney (AU)
- UNSW Sydney (AU)
- Prince of Wales Hospital (AU)
- Neuroscience Research Australia (AU)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.093242
- Primary Topic
- Health, psychology, and well-being
- Type
- article
- Field-Weighted Citation Impact
- 0.00