Functional connectivity associations with markers of disease progression in <i>GRN</i> mutation carriers
In presymptomatic carriers, the co-occurrence of hyperconnectivity, high NfL, and low gray matter suggests that tf-fMRI hyperconnectivity may portend the onset of the neurodegenerative phase. These findings point toward hyperconnectivity as an indicator of approaching symptomatic onset.
Authors
- Sandra Weıntraub (ORCID: https://orcid.org/0000-0003-2605-5205)
- Julio C. Rojas (ORCID: https://orcid.org/0000-0002-1308-646X)
- Irene Litvan (ORCID: https://orcid.org/0000-0002-3485-3445)
- Hilary W. Heuer (ORCID: https://orcid.org/0000-0002-3776-1685)
- Arthur W. Toga (ORCID: https://orcid.org/0000-0001-7902-3755)
- Maria Carmela Tartaglia (ORCID: https://orcid.org/0000-0002-5944-8497)
- Lorenzo Pasquini (ORCID: https://orcid.org/0000-0002-7899-7061)
- Daniel H. Geschwind (ORCID: https://orcid.org/0000-0003-2896-3450)
- Adam L. Boxer (ORCID: https://orcid.org/0000-0002-1215-5064)
- Suvi Häkkinen (ORCID: https://orcid.org/0000-0002-6396-1904)
- Alex J. Lee (ORCID: https://orcid.org/0000-0003-0001-2848)
- Kimiko Domoto‐Reilly (ORCID: https://orcid.org/0000-0002-7396-1633)
- Eric J. Huang (ORCID: https://orcid.org/0000-0002-5381-3801)
- David McFall (ORCID: https://orcid.org/0009-0007-2359-2810)
- Stephanie A. Chu (ORCID: https://orcid.org/0000-0001-5749-2139)
- Bruce L. Miller (ORCID: https://orcid.org/0000-0002-2152-4220)
- Brad C. Dickerson
- Chiadi U. Onyike (ORCID: https://orcid.org/0000-0003-2255-4437)
- Murray Grossman (ORCID: https://orcid.org/0000-0002-7447-6218)
- Kristen Fernhoff
- Daniel Kaufer (ORCID: https://orcid.org/0000-0002-9629-3455)
- Ian R. Mackenzie (ORCID: https://orcid.org/0000-0003-3875-2972)
- Leonard Petrucelli (ORCID: https://orcid.org/0000-0003-2959-129X)
- David S. Knopman (ORCID: https://orcid.org/0000-0002-6544-066X)
- Ging‐Yuek Robin Hsiung (ORCID: https://orcid.org/0000-0002-8017-0856)
- Jennifer S. Yokoyama (ORCID: https://orcid.org/0000-0001-7274-2634)
- Maria Luisa Mandelli (ORCID: https://orcid.org/0000-0002-2518-2520)
- Liwen Zhang (ORCID: https://orcid.org/0000-0002-8533-9075)
- Bradley F. Boeve (ORCID: https://orcid.org/0000-0002-4153-8187)
- Virginia E. Sturm (ORCID: https://orcid.org/0000-0002-1717-298X)
- Taru Flagan (ORCID: https://orcid.org/0009-0003-6566-9696)
- Howard J. Rosen (ORCID: https://orcid.org/0000-0001-9281-7402)
- William W. Seeley (ORCID: https://orcid.org/0000-0003-1410-2027)
- Leah K. Forsberg (ORCID: https://orcid.org/0000-0003-4086-9598)
- Kejal Kantarci (ORCID: https://orcid.org/0000-0002-8001-2081)
- Edward D. Huey (ORCID: https://orcid.org/0000-0002-8295-5884)
- Brian S. Appleby (ORCID: https://orcid.org/0000-0003-2275-3292)
- Mario F. Mendez (ORCID: https://orcid.org/0000-0001-6441-7989)
- Carolin Heller (ORCID: https://orcid.org/0000-0002-1934-6162)
- Erik D. Roberson (ORCID: https://orcid.org/0000-0002-1810-9763)
- Fermín Moreno (ORCID: https://orcid.org/0000-0001-5200-3164)
- Nupur Ghoshal (ORCID: https://orcid.org/0000-0002-6680-6731)
- Jesse A. Brown (ORCID: https://orcid.org/0000-0002-3139-9451)
- Neill R. Graff‐Radford (ORCID: https://orcid.org/0000-0001-9847-9096)
- Suzee E. Lee (ORCID: https://orcid.org/0009-0004-3295-6346)
- Eliana Marisa Ramos (ORCID: https://orcid.org/0009-0003-7982-4415)
- Anna M. Karydas
- Tatiana M. Foroud
- Jonathan D. Rohrer
- Maria Luisa Gorno Tempini
Institutions
- Northwestern University (US)
- University of North Carolina at Chapel Hill (US)
- University of Southern California (US)
- University Health Network (CA)
- Mayo Clinic (US)
- University of British Columbia (CA)
- Johns Hopkins University (US)
- University of California, Los Angeles (US)
- University of California, San Francisco (US)
- University of Washington (US)
- Washington University in St. Louis (US)
- Brown University (US)
- Toronto Western Hospital (CA)
- Johns Hopkins Medicine (US)
- WinnMed (US)
- University of Alabama at Birmingham (US)
- University of California San Diego (US)
- Massachusetts General Hospital (US)
- University Memory and Aging Center (US)
- Mayo Clinic in Arizona (US)
- UK Dementia Research Institute (GB)
- Mayo Clinic in Florida (US)
- National Hospital for Neurology and Neurosurgery (GB)
- Indiana University School of Medicine
- University College London (GB)
- Indiana University – Purdue University Indianapolis (US)
- Case Western Reserve University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087301
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00