Evidence of recent evolutionary selection at eQTLs for APOE
We identified evidence of recent natural selection in APOE eQTLs in two East Asian populations: rs1628394 in Kinh Vietnamese and rs2909088 in Han Chinese. Prior work has established that rs1628394 is nominally associated with LOAD (p = 2.45 × 10<sup>-3</sup>) and the genome Aggregation Database indicates that it is common in Africans (AF = 0.63), less common in Europeans (AF = 0.33), and least common in East Asians (AF = 0.13). The second SNP, rs2909088, is not associated with LOAD, but it is also less common in East Asians (AF<sub>European</sub> = 0.87, AF<sub>African</sub> = 0.69, and AF<sub>EastAsian =</sub> 0.38). Recent selection at rs1628394 may be enhancing the impact of APOE4 on LOAD development in Kinh Vietnamese.
Authors
- Giuseppe Tosto (ORCID: https://orcid.org/0000-0001-7075-8245)
- Scott M. Williams (ORCID: https://orcid.org/0000-0002-4835-9544)
- Jonathan L. Haines (ORCID: https://orcid.org/0000-0002-4351-4728)
- Rufus Akinyemi (ORCID: https://orcid.org/0000-0001-5286-428X)
- Razaq O Durodoye
- Timothy H. Ciesielski
- Farid Rajabli
- Margaret A Pericak‐Vance
Institutions
- University of Miami (US)
- University of Ibadan (NG)
- Dr. John T. Macdonald Foundation (US)
- Case Western Reserve University (US)
- Columbia University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092921
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00