Seizure‐activated neurons facilitate tau spread in 5XFAD mice
Together, our data demonstrate that seizures increase tau spread in mouse models and identify seizures and seizure-activated neurons as therapeutic targets to slow pathological AD progression.
Authors
- Abigail Chavez
- Aaron J Barbour (ORCID: https://orcid.org/0000-0002-4880-6797)
- Delia M. Talos (ORCID: https://orcid.org/0009-0009-5346-8954)
- Frances E. Jensen (ORCID: https://orcid.org/0000-0001-7844-5518)
- Virginia M.‐Y. Lee (ORCID: https://orcid.org/0000-0003-3536-6902)
- Keegan Hoag
- Xiaofan Li
- Chloe Hassman
Institutions
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.090886
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00