Integrative multi‐omics epigenome‐wide association study identifies dysregulated DNA methylation near oligodendrocyte genes that associate with tau levels in the AD brain
Although all endophenotypes tested are core to AD pathophysiology, our results suggest each has a distinct epigenetic architecture underlying their variability in the AD brain. In particular, we found evidence of DNAm variability associating with brain oligodendrocyte gene expression and TCX tau levels. By discovering AD brain endophenotype-specific DNAm changes, we can identify core components of complex mechanisms revealing important biological insights into AD pathophysiology.
Authors
- Dennis W. Dickson (ORCID: https://orcid.org/0000-0001-7189-7917)
- Joseph S. Reddy (ORCID: https://orcid.org/0000-0002-1783-4453)
- Michael DeTure (ORCID: https://orcid.org/0000-0002-4363-1262)
- Guojun Bu (ORCID: https://orcid.org/0000-0003-3491-1016)
- Michael G. Heckman (ORCID: https://orcid.org/0000-0003-3770-9331)
- Takahisa Kanekiyo (ORCID: https://orcid.org/0000-0001-6751-9374)
- Na Zhao (ORCID: https://orcid.org/0000-0001-8648-9422)
- Melissa E. Murray (ORCID: https://orcid.org/0000-0001-7379-2545)
- Özkan İş (ORCID: https://orcid.org/0000-0003-4070-6756)
- Minerva M. Carrasquillo (ORCID: https://orcid.org/0000-0002-3231-9134)
- Yu Yamazaki (ORCID: https://orcid.org/0000-0002-0806-4960)
- Chia‐Chen Liu (ORCID: https://orcid.org/0000-0001-7203-3926)
- Nilüfer Ertekin‐Taner (ORCID: https://orcid.org/0000-0003-4436-8889)
- Stephanie R. Oatman
- Mariet Allen (ORCID: https://orcid.org/0000-0002-2685-427X)
- Zachary Quicksall (ORCID: https://orcid.org/0000-0002-8791-0925)
- Xue Wang (ORCID: https://orcid.org/0000-0002-7563-963X)
- Thuy Nguyen (ORCID: https://orcid.org/0000-0003-2971-4077)
- Jeremiah Bergman
- Amin Atashgaran (ORCID: https://orcid.org/0009-0002-9051-0989)
- Floor Vanelderen
Institutions
- WinnMed (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087790
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00