Potentially heritable biomarkers of neurodegeneration in a marmoset model of Alzheimer’s disease
Correlations between AD-relevant biomarkers in marmosets exceeded those observed in humans, which were not explained by age. This suggests a strong potential genetic contribution. Leveraging possible heritable associations with disease markers discovered in the marmosets to explain the progression of neurodegeneration could directly provide insights into human AD biology from a genetic point of view.
Authors
- Yongshan Mou
- Seung‐Kwon Ha
- Gregory W. Carter (ORCID: https://orcid.org/0000-0002-2834-8186)
- Takeshi Murai (ORCID: https://orcid.org/0000-0002-0429-4195)
- Sangho Choi (ORCID: https://orcid.org/0009-0006-9106-7818)
- Afonso C. Silva (ORCID: https://orcid.org/0000-0002-6105-7567)
- Catrina Spruce
- Stacey J. Sukoff Rizzo (ORCID: https://orcid.org/0000-0002-1460-8127)
- Hasi Huhe
- Annat Haber (ORCID: https://orcid.org/0000-0001-8407-9171)
- Gregg E. Homanics (ORCID: https://orcid.org/0000-0003-3641-8153)
- Brianne Stein
- Laura M. Schultz (ORCID: https://orcid.org/0000-0001-7506-8235)
- Lauren S. Bailey (ORCID: https://orcid.org/0000-0002-7155-5877)
- Stephanie Hachem
- Lauren Mongeau
- Andrew DeSana (ORCID: https://orcid.org/0009-0009-4361-7637)
- Sonal Kumar (ORCID: https://orcid.org/0000-0002-6873-6933)
- Lauren K Hayrynen Schaeffer
- Jung Eun Park (ORCID: https://orcid.org/0009-0000-1474-0905)
Institutions
- Tufts University (US)
- University of Pittsburgh (US)
- Jackson Laboratory (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.090952
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00