Unraveling the interplay between tau seeding and autophagy processes

Together, my in vitro and in vivo studies are starting to unravel the molecular details of the interplay between tau seeding and autophagy. These studies have the ability to reveal novel strategies to reduce the toxicity of tau aggregates by stimulating the activity of the autophagic machinery. Research approaches addressing tau in general, and tau seeding more specifically, have enormous potential to provide highly innovative, disease-modifying first-in-class therapeutics for AD. References 1) Holmes BB et al. (2014) "Proteopathic tau seeding predicts tauopathy in vivo. Proc Natl Acad Sci USA. 111: E4376-E4385 2) Doench JG et al. (2016) "Optimized sgRNA design to maximise activity and minimise off-target effects of CRISPR-Cas9." Nat. Biotechnol. 34: 184-191.