Social determinants of health and not global genetic ancestry predicts cognitive performance and dementia risk in Latinos
We report a comprehensive characterization of the role of global genetic ancestry in cognitive performance and dementia in Latin America while controlling for SDoH. In our study, adjustment of SDoH attenuated associations between genetic ancestry, dementia probability, and cognitive performance. These findings highlight that social and environmental factors likely play more critical roles than genetic ancestry in determining racial/ethnic disparities in cognitive performance and subsequent dementia risk.
Authors
- Alan E. Renton (ORCID: https://orcid.org/0000-0001-6702-8268)
- Juan J. Llibre Rodríguez (ORCID: https://orcid.org/0000-0002-8215-3160)
- Juan Carlos Llibre Guerra
- Ana M Rodriguez‐Salgado
- Ana Luisa Sosa (ORCID: https://orcid.org/0000-0003-3930-3618)
- Jennifer S. Yokoyama (ORCID: https://orcid.org/0000-0001-7274-2634)
- Mariella Guerra (ORCID: https://orcid.org/0000-0001-8923-349X)
- Matthew Prina (ORCID: https://orcid.org/0000-0001-6698-3263)
- Isaac Acosta (ORCID: https://orcid.org/0000-0002-8664-9542)
- Ivonne Z. Jiménez Velázquez
- Jorge J. Llibre‐Guerra (ORCID: https://orcid.org/0000-0002-2137-7750)
- Miao Jiang (ORCID: https://orcid.org/0000-0002-3681-9494)
- Aquiles Salas (ORCID: https://orcid.org/0000-0003-4687-2448)
- Daisy Acosta (ORCID: https://orcid.org/0000-0002-5196-8578)
- N Sanchez
Institutions
- Allen Institute for Brain Science (US)
- University of California, San Francisco (US)
- Universidad de Salamanca (ES)
- Universidad Peruana Cayetano Heredia (PE)
- University of Puerto Rico System (PR)
- Washington University in St. Louis (US)
- University of Havana (CU)
- University Memory and Aging Center (US)
- Universidad Nacional Pedro Henríquez Ureña (DO)
- Instituto Nacional de Neurología y Neurocirugía (MX)
- Global Brain Health Institute (US)
- Università della Svizzera italiana (CH)
- Universidad Central de Venezuela (VE)
- Newcastle University (GB)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.086626
- Primary Topic
- Health disparities and outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00