IGFBP‐5 Potentially Mediates the Association of Brain Insulin Signaling with Late‐Life Cognitive Decline
AD-related cortical proteins IGFBP-5 and ITPK1 are each associated with insulin signaling AKT1 phosphorylation in postmortem human brain. Further, IGFBP-5 potentially mediates the association of AKT1 phosphorylation with late-life cognitive decline.
Authors
- David Alan Bennett (ORCID: https://orcid.org/0000-0003-3689-554X)
- Ana W. Capuano (ORCID: https://orcid.org/0000-0002-3505-344X)
- Zoe Arvanitakis (ORCID: https://orcid.org/0000-0001-7477-8884)
- Rexford S. Ahima (ORCID: https://orcid.org/0000-0002-3479-1942)
- Steven Edward Arnold (ORCID: https://orcid.org/0000-0002-9487-415X)
- Han Tong (ORCID: https://orcid.org/0000-0002-9821-5928)
Institutions
- Rush University Medical Center (US)
- Harvard University (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087777
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00