Quantitative effects of sleep‐disrupting medications on real‐world sleep metrics in older adults at risk for neurodegeneration

Our results, using RWD of sleep and medications, underscore that polypharmacy in older adults is associated with disrupted sleep patterns, with a greater number of sleep-disrupting medications exacerbating poor sleep outcomes. These findings highlight needs for careful medication management to preserve sleep and suggest that targeted pharmacological strategies can mitigate medication-related sleep disturbances, thereby enhancing brain health, behavior, and overall health.