Macroscale structural covariance network reveals the biological mechanisms of neuropsychiatric symptoms in the Alzheimer’s continuum

This is the first study to identify three distinct NPS subtypes in the AD continuum through a data-driven approach, bridging the gap in the knowledge on the contributions of NPSs to the onset and development of AD. Our study constitutes a step toward resolving stagnant research progress on NPS management strategies based on clinical symptoms, and offers new insights into precise interventions for these patients.