Neuropathological and cell type‐specific effects of Kv1.3 blockers in a pre‐clinical AD mouse model
Our studies re-affirm beneficial neuropathological effects of pharmacological Kv1.3 blockade in Ab models, and additionally reveal differential effects and mechanisms of membrane permeable and brain penetrant versus non-permeant Kv1.3 blockers. PAP-1 prominently affects microglia and oligodendrocytes, suggesting they may be potential targets of Kv1.3 blockade. Additionally, evidence indicates pro-myelination and synaptic-protective effects of Kv1.3 blockade.
Authors
- Steven A. Sloan (ORCID: https://orcid.org/0000-0001-7769-7684)
- Anson Sing
- Srikant Rangaraju (ORCID: https://orcid.org/0000-0003-2765-1500)
- Heike Wulff (ORCID: https://orcid.org/0000-0003-4437-5763)
- Prateek Kumar (ORCID: https://orcid.org/0000-0001-5875-4065)
- Caitlin Sojka (ORCID: https://orcid.org/0000-0003-0902-8694)
- Tarun N. Bhatia (ORCID: https://orcid.org/0000-0002-3046-6659)
- Hollis Zeng
- Maureen M. Sampson (ORCID: https://orcid.org/0000-0003-1536-3229)
- Christine A Bowen (ORCID: https://orcid.org/0000-0002-2981-8629)
- Upasna Srivastava (ORCID: https://orcid.org/0000-0003-4096-9257)
- Hailian Xiao (ORCID: https://orcid.org/0000-0002-3796-4693)
Institutions
- Emory University (US)
- Yale University (US)
- Institute for Neurodegenerative Disorders (US)
- University of California, Davis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091970
- Primary Topic
- Receptor Mechanisms and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00