The association between focal prefrontal cortical atrophy and accelerated long‐term forgetting in presymptomatic autosomal dominant Alzheimer’s disease
ALF is an early presymptomatic marker of AD-related cognitive decline, underscored by changes in the PFC but not the MTL. These findings advance our understanding of the neuroanatomical substrate of early AD memory decline. ALF could be used as a biologically relevant measure in future presymptomatic trials.
Authors
- Philip S.J. Weston (ORCID: https://orcid.org/0000-0003-1033-9916)
- Kirsty Lu (ORCID: https://orcid.org/0000-0002-8416-2183)
- Nick C. Fox (ORCID: https://orcid.org/0000-0002-6660-657X)
- Maggie R Fraser (ORCID: https://orcid.org/0000-0002-1142-957X)
- Antoinette O’Connor (ORCID: https://orcid.org/0000-0003-4467-128X)
- Sebastian J. Crutch (ORCID: https://orcid.org/0000-0002-4160-0139)
- C.M.A. Young
Institutions
- UK Dementia Research Institute (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092404
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00