African ancestry component could change APOE4 effect size for AD of a diverse population
Our sample is composed by a heterogeneous genetic ancestry, different from the other Latin America populations. APOE4 allele presented a lower effect size to AD than some other populations. This result could be related to two other variants, associated with the African component, influencing the effect of APOE4 allele.
Authors
- Bernardo de Mattos Viana (ORCID: https://orcid.org/0000-0001-8792-2996)
- Alfredo Ramı́rez (ORCID: https://orcid.org/0000-0003-4991-763X)
- Kayenat Parveen
- Marco Túlio Gualberto Cintra (ORCID: https://orcid.org/0000-0003-3089-655X)
- Gabriela Tomé Oliveira Engelmann
- Carolina Dalmasso (ORCID: https://orcid.org/0000-0002-4901-9955)
- Débora Marques de Miranda (ORCID: https://orcid.org/0000-0002-7081-8401)
- Érika de Oliveira Hansen
- Ivonne Carolina Bolaños Burgos (ORCID: https://orcid.org/0000-0002-9602-3850)
- Marco Aurélio Romano‐Silva (ORCID: https://orcid.org/0000-0002-6558-4639)
- Luiz Armando Cunha de Marco
- Maria Aparecida Camargos Bicalho
Institutions
- Universidade Federal de Minas Gerais (BR)
- University of Bonn (DE)
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- University of Cologne (DE)
- University Hospital Bonn (DE)
- German Center for Neurodegenerative Diseases (DE)
- Faculdade de Ciências Médicas de Minas Gerais (BR)
- Institute for Neurodegenerative Disorders (US)
- Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE)
- University Hospital Cologne (DE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091733
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00