Cortico‐hippocampal dysfunction in APP‐KI and PS1 mouse models
Our findings suggest that during an age period when Alzheimer's disease phenotypes are already established, there is a markedly reduction in the connectivity between LEC, MEC and hippocampus with an episodic memory performance impaired. Current analysis to determine the precise period of the cortico-hippocampal dysfunction appears during the disease progression are underway.
Authors
- Jayeeta Basu (ORCID: https://orcid.org/0000-0002-7559-0936)
- Melissa Hernández‐Frausto (ORCID: https://orcid.org/0000-0002-6300-8988)
- Francesca Chinea
Institutions
- Harvard University (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087004
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00