Longitudinal cognitive outcomes are strongly correlated with the Alzheimer’s Disease microbiome

Not only is the gut microbiome composition highly predictive of AD diagnosis, but there is also a strong correlation of the gut microbiome and cognitive functioning. This is true across the multiple domains of cognition including memory, executive function and language, however different bacterial species were significant in associating with each domain. This work highlights the complexity of the microbiome-gut-brain axis and how the microbiome community makeup might play a role in cognitive decline.