Whole genome methylation sequencing in blood reveals differential DNA methylation in pathways associated with mitochondrial function in persons with late‐onset dementia due to Alzheimer’s disease (AD)
Disordered pathways that participate in beta-oxidation and fatty acid metabolism have been identified in large-scale multi-omic reports of AD histopathology. Present data indicate that corresponding changes in the methylome play a role in mitochondrial pathways known to contribute to the pathogenesis of AD and may serve as candidates for diagnosis and intervention.
Authors
- Alexander E. Boruch (ORCID: https://orcid.org/0000-0001-8825-3763)
- Andy Madrid (ORCID: https://orcid.org/0000-0001-8612-5995)
- Dane B. Cook (ORCID: https://orcid.org/0000-0002-3992-4820)
- Sündüz Keleş (ORCID: https://orcid.org/0000-0001-9048-0922)
- Reid S. Alisch (ORCID: https://orcid.org/0000-0003-0637-4137)
- Kirk J. Hogan (ORCID: https://orcid.org/0000-0001-6329-2651)
- Ligia A. Papale (ORCID: https://orcid.org/0000-0002-6457-0358)
- Coleman Breen (ORCID: https://orcid.org/0000-0003-1227-7712)
- Lindsay R. Clark (ORCID: https://orcid.org/0000-0003-4837-7627)
- Sanjay Asthana (ORCID: https://orcid.org/0000-0002-3998-4479)
- Sterling C. Johnson
- Isabelle Renteria
- Phillip E. Bergmann (ORCID: https://orcid.org/0000-0002-1049-8661)
Institutions
- University of Wisconsin–Madison (US)
- Geriatric Research Education and Clinical Center (US)
- William S. Middleton Memorial Veterans Hospital (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.088336
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00