Sex differences in familial forms of frontotemporal dementia
In familial FTD, women evidenced steeper clinical declines than men after symptom onset. Accounting for pathology, baseline NfL was a stronger predictor of clinical decline in asymptomatic men compared to women. NfL may be a less sensitive prognostic tool for clinical progression in women with FTD, particularly early in disease. This may reflect early "cognitive resilience" to neurodegeneration in women.
Authors
- Hilary W. Heuer (ORCID: https://orcid.org/0000-0002-3776-1685)
- Adam M. Staffaroni (ORCID: https://orcid.org/0000-0002-3903-9805)
- Anna M. VandeBunte (ORCID: https://orcid.org/0000-0002-5167-3358)
- John Kornak (ORCID: https://orcid.org/0000-0002-0089-0619)
- Rowan Saloner (ORCID: https://orcid.org/0000-0002-1351-6183)
- Ignacio Illán‐Gala (ORCID: https://orcid.org/0000-0002-5418-2052)
- Molly B Memel
- Kaitlin Blackstone Casaletto (ORCID: https://orcid.org/0000-0001-5000-7604)
- Claire J. Cadwallader (ORCID: https://orcid.org/0000-0003-3449-3803)
- Bradley F. Boeve (ORCID: https://orcid.org/0000-0002-4153-8187)
- Leah K. Forsberg (ORCID: https://orcid.org/0000-0003-4086-9598)
- Tania F. Gendron (ORCID: https://orcid.org/0000-0002-7335-2627)
- Emily W. Paolillo (ORCID: https://orcid.org/0000-0003-4188-6998)
- Adam L. Boxer
- Howard J. Rosen
- Coty Chen
Institutions
- Universitat Autònoma de Barcelona (ES)
- Mayo Clinic (US)
- University of California, San Francisco (US)
- Hospital de Sant Pau (ES)
- WinnMed (US)
- University Memory and Aging Center (US)
- Mayo Clinic in Florida (US)
- Institut de Recerca Sant Pau (ES)
- University of San Francisco (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092552
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00