Apolipoprotein ε genotype and sex influences skeletal muscle bioenergetic response to diet
HFD-driven upregulation of proteins involved in carbohydrate metabolism in APOE4 female muscle only likely supports increased carbohydrate oxidative capacity and may explain the lack of reduction in serum lactate in this group. Proteomic analysis of human muscle is ongoing to determine if this is reflected in humans.
Authors
- Colin S. McCoin (ORCID: https://orcid.org/0000-0002-8557-6441)
- Jill K. Morris (ORCID: https://orcid.org/0000-0001-5911-4190)
- Heather Wilkins (ORCID: https://orcid.org/0000-0003-4563-4544)
- Colton R Lysaker
- Chelsea N. Johnson (ORCID: https://orcid.org/0000-0003-2827-3265)
- Paige C. Geiger (ORCID: https://orcid.org/0000-0002-3990-7246)
- John P. Thyfault (ORCID: https://orcid.org/0000-0001-7920-7466)
- Riley E. Kemna
- Casey S. John
Institutions
- University of Kansas (US)
- University of Kansas Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.086251
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00