Relationships between locus coeruleus microstructural integrity, sleep, and 24‐h rest‐activity rhythm in the context of plasma markers of Alzheimer’s disease: a 7T MRI study of asymptomatic older individuals

These preliminary results suggest that poorer LC microstructural integrity is linked to worse proxy measures of sleep quality and circadian rest-activity patterns, but only in individuals with elevated levels of AD pathology. Our findings therefore provide novel evidence of the involvement of the LC in sleep-wake phenotypes in older adults in the context of AD pathophysiological processes, and have implications for the identification of individuals at higher risk for AD-related sleep-wake disturbances.