Amyloid‐positivity is characterized by decline in semantic fluency: An in‐depth investigation of verbal fluency trajectories, item‐level characteristics and its prognostic value in patients with subjective cognitive decline
Longitudinal decline in semantic fluency and discrepancy scores, but not phonemic fluency, was associated with amyloid positivity in individuals with SCD. Baseline fluency did not predict clinical progression. These findings suggest that longitudinal follow-up is essential to capture semantic fluency decline that is associated with AD pathophysiology.
Authors
- Argonde C. van Harten (ORCID: https://orcid.org/0000-0002-1477-8724)
- Wiesje M. van der Flier (ORCID: https://orcid.org/0000-0001-8766-6224)
- Elsmarieke van de Giessen
- Elke Butterbrod
- Sietske A.M. Sikkes (ORCID: https://orcid.org/0000-0002-0161-3656)
- Charlotte Elisabeth Teunissen (ORCID: https://orcid.org/0000-0002-4061-0837)
- Casper de Boer
- Rosanne L. van den Berg (ORCID: https://orcid.org/0009-0008-0685-9074)
- Demi van de Scheur
- Lisa‐Marie Schlüter
Institutions
- Amsterdam Neuroscience (NL)
- Amsterdam University Medical Centers (NL)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.088963
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.39