Harbingers of Disease: Decoding Shared Multi‐Omic Changes in Human and Mouse Models of Alzheimer’s Disease

This study successfully decodes shared multi-omic changes in human and mouse models of Alzheimer's Disease, highlighting key molecular similarities and differences across species. The findings underscore the significance of a multi-faceted, integrated omic approach in understanding AD pathogenesis. This cross-species analysis not only advances our knowledge of the molecular underpinnings of AD but also opens avenues for developing more accurate and translatable AD models, ultimately guiding the discovery of potential therapeutic targets.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2024-12-01
DOI
https://doi.org/10.1002/alz.087010
Primary Topic
Single-cell and spatial transcriptomics
Type
article
Field-Weighted Citation Impact
0.00
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article

Harbingers of Disease: Decoding Shared Multi‐Omic Changes in Human and Mouse Models of Alzheimer’s Disease

Emily Miyoshi, Samuel Morabito, Vivek Swarup, Kim N. Green et al.
Alzheimer s & Dementia
Single-cell and spatial transcriptomics
article

Harbingers of Disease: Decoding Shared Multi‐Omic Changes in Human and Mouse Models of Alzheimer’s Disease

Emily Miyoshi, Samuel Morabito, Vivek Swarup, Kim N. Green, Elizabeth Head
article en

Abstract

This study successfully decodes shared multi-omic changes in human and mouse models of Alzheimer's Disease, highlighting key molecular similarities and differences across species. The findings underscore the significance of a multi-faceted, integrated omic approach in understanding AD pathogenesis. This cross-species analysis not only advances our knowledge of the molecular underpinnings of AD but also opens avenues for developing more accurate and translatable AD models, ultimately guiding the discovery of potential therapeutic targets.

Alzheimer s & DementiaVol. 20(S1)
University of California, Irvine (US)
Life in Land
Openalex Percentile: Top 78%
Single-cell and spatial transcriptomics
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