Harbingers of Disease: Decoding Shared Multi‐Omic Changes in Human and Mouse Models of Alzheimer’s Disease
This study successfully decodes shared multi-omic changes in human and mouse models of Alzheimer's Disease, highlighting key molecular similarities and differences across species. The findings underscore the significance of a multi-faceted, integrated omic approach in understanding AD pathogenesis. This cross-species analysis not only advances our knowledge of the molecular underpinnings of AD but also opens avenues for developing more accurate and translatable AD models, ultimately guiding the discovery of potential therapeutic targets.
Authors
- Emily Miyoshi (ORCID: https://orcid.org/0000-0001-8151-0560)
- Samuel Morabito (ORCID: https://orcid.org/0000-0002-7768-4856)
- Vivek Swarup (ORCID: https://orcid.org/0000-0003-3762-2746)
- Kim N. Green (ORCID: https://orcid.org/0000-0002-6049-6744)
- Elizabeth Head (ORCID: https://orcid.org/0000-0003-1115-6396)
Institutions
- University of California, Irvine (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087010
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00