Correlation between changes in apathy and cognition in Alzheimer’s disease associated apathy: analysis of the Apathy in Dementia Methylphenidate Trial 2 (ADMET 2)
Changes in apathy are associated with changes in cognition as part of the natural history of AD. However, this association is disrupted by MPH treatment and suggests that improvements in apathy in AD with MPH were not driven by cognitive changes. These results are consistent with the view that apathy as a syndrome is related to, but distinct from cognition.
Authors
- Krushnaa Sankhe (ORCID: https://orcid.org/0000-0003-0535-4935)
- Shankar Tumati (ORCID: https://orcid.org/0000-0001-5703-2044)
- Luc Rivet
- Suzanne Craft (ORCID: https://orcid.org/0000-0003-0591-8657)
- Allan I. Levey (ORCID: https://orcid.org/0000-0002-3153-502X)
- Anton P. Porsteinsson (ORCID: https://orcid.org/0000-0002-0166-1738)
- Danielle Soares Rocha Vieira (ORCID: https://orcid.org/0000-0001-6222-6142)
- Krista L. Lanctôt (ORCID: https://orcid.org/0000-0001-7024-6637)
- Alan J. Lerner (ORCID: https://orcid.org/0000-0001-9447-6154)
- Paul B. Rosenberg (ORCID: https://orcid.org/0000-0003-1106-4299)
- David Shade
- Jamie Perin (ORCID: https://orcid.org/0000-0002-5482-6620)
- Nathan Herrmann (ORCID: https://orcid.org/0000-0001-9277-6110)
- Prasad R. Padala (ORCID: https://orcid.org/0000-0003-1921-9806)
- Christopher H. van Dyck (ORCID: https://orcid.org/0000-0003-1779-097X)
- Olga Brawman‐Mintzer
- Jacobo Mintzer
Institutions
- Sunnybrook Health Science Centre (CA)
- Johns Hopkins University (US)
- Emory University (US)
- Medical University of South Carolina (US)
- University of Toronto (CA)
- University Hospitals of Cleveland (US)
- Johns Hopkins Medicine (US)
- Health Sciences Centre (CA)
- Central Arkansas Veterans Healthcare System (US)
- Sunnybrook Hospital (CA)
- Sunnybrook Research Institute
- Wake Forest University (US)
- University of Rochester (US)
- University of Arkansas for Medical Sciences (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091793
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00