Sensitive methods to define subtle memory decline capture intra‐individual hippocampal atrophy and increased cortical volumes in preclinical Alzheimer’s
Episodic memory obj-SCD captured longitudinal changes in GMv indicative of AD-progression (i.e., hippocampus). These results suggested that episodic memory obj-SCD is a consistent marker of AD-related impairment. Characterizing obj-SCD enhances preclinical stage identification, with implications for advancing early detection and intervention strategies in Alzheimer's disease, informing about an elevated risk of AD-dementia in an otherwise CU population.
Authors
- Marta Milà‐Alomà (ORCID: https://orcid.org/0000-0002-5687-4597)
- Gonzalo Sánchez‐Benavides (ORCID: https://orcid.org/0000-0003-3454-800X)
- Raffaele Cacciaglia (ORCID: https://orcid.org/0000-0002-9216-949X)
- Juan Domingo Gispert (ORCID: https://orcid.org/0000-0002-6155-0642)
- Oriol Grau‐Rivera (ORCID: https://orcid.org/0000-0002-4730-5341)
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Marc Suárez‐Calvet (ORCID: https://orcid.org/0000-0002-2993-569X)
- Carolina Minguillón (ORCID: https://orcid.org/0000-0002-2782-6908)
- David López‐Martos (ORCID: https://orcid.org/0009-0008-1150-2619)
- Kaj Blennow
Institutions
- University of Wisconsin–Madison (US)
- University of California, San Francisco (US)
- Sahlgrenska University Hospital (SE)
- Instituto de Salud Carlos III (ES)
- Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (ES)
- Pasqual Maragall Foundation (ES)
- Barcelonaβeta Brain Research Center (ES)
- Hospital Del Mar (ES)
- Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (ES)
- National Hospital for Neurology and Neurosurgery (GB)
- Hospital del Mar Research Institute (ES)
- Northern California Institute for Research and Education (US)
- University College London (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.085873
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.39