Associations between performance on a non‐immersive virtual reality task and structural correlates of Alzheimer’s disease vulnerable brain regions
In contrast to conventional measures, VKC outcomes were significantly associated with entorhinal and inferior temporal cortex thickness, brain regions that are typically affected early in AD-disease progression. Overall, the VKC, particularly measures of completion time and proportion of time off screen, holds promise as a highly sensitive and valid, objective measure of everyday function in a range of contexts with racially diverse older adults, including clinical assessment and clinical trials.
Authors
- Ingrid R. Olson (ORCID: https://orcid.org/0000-0001-8947-6432)
- Sophia Holmqvist (ORCID: https://orcid.org/0000-0001-7303-3338)
- Tania Giovannetti (ORCID: https://orcid.org/0000-0001-5661-152X)
- Katie R. Jobson (ORCID: https://orcid.org/0000-0002-9078-2733)
- Molly B. Tassoni (ORCID: https://orcid.org/0000-0001-6822-3794)
- Moira Mckniff
- Dennis DeSalme
- Nadine Martin (ORCID: https://orcid.org/0000-0003-1423-7191)
- Takehiko Yamaguchi (ORCID: https://orcid.org/0009-0000-2707-7380)
- Stephanie M. Simone
Institutions
- Suwa Red Cross Hospital (JP)
- Temple University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.085996
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00