<i>APOE4</i> to <i>APOE2</i> ‘Switching’ in Astrocytes Alters the Cerebral Transcriptome and Decreases AD Neuropathology at Different Points on the AD Pathophysiological Timeline
Together, these data suggest that a successful transition from E4 to E2 in astrocytes has broad impact on the cerebral transcriptome and that an astrocyte-specific E4 to E2 'switch' improves multiple AD-associated pathologies at different points across the AD pathophysiological timeline.
Authors
- Lance A. Johnson (ORCID: https://orcid.org/0000-0003-0134-7586)
- Kumar Pandya
- Lesley R. Golden (ORCID: https://orcid.org/0000-0001-8922-8850)
- Scott M. Gordon (ORCID: https://orcid.org/0000-0001-9532-032X)
- Josh M. Morganti (ORCID: https://orcid.org/0000-0002-4183-0049)
- Steven M. MacLean (ORCID: https://orcid.org/0000-0003-1359-6731)
- Isaiah O. Stephens (ORCID: https://orcid.org/0009-0007-7070-1805)
- Dahlia Siano
Institutions
- University of North Carolina at Chapel Hill (US)
- University of Kentucky (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.090743
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00