Data‐driven Cognitive Composites and <i>APOE</i> ε4 Carriage Predict Progression to Mild Cognitive Impairment in Cognitively Unimpaired Older Adults
Together with APOE ε4 carriage, our PCA-derived domain-specific composites performed better than their summed z-score counterparts at predicting progression to MCI 15 years before symptom onset.
Authors
- Vincent Doré (ORCID: https://orcid.org/0000-0002-8051-0558)
- James D. Doecke (ORCID: https://orcid.org/0000-0003-2863-0293)
- Jürgen Fripp
- Hamid R. Sohrabi (ORCID: https://orcid.org/0000-0001-8017-8682)
- Yen Ying Lim (ORCID: https://orcid.org/0000-0002-0308-5156)
- Colin L. Masters (ORCID: https://orcid.org/0000-0003-3072-7940)
- Eleanor K. O’Brien (ORCID: https://orcid.org/0000-0001-5145-7340)
- Liang Jin (ORCID: https://orcid.org/0000-0003-1695-3300)
- Paul Maruff (ORCID: https://orcid.org/0000-0002-6947-9537)
- Brook Galna (ORCID: https://orcid.org/0000-0002-5890-1894)
- Rosita Shishegar (ORCID: https://orcid.org/0000-0002-2454-3443)
- Belinda M. Brown (ORCID: https://orcid.org/0000-0001-7927-2540)
- Shaun Markovic (ORCID: https://orcid.org/0000-0003-3879-5040)
- Samantha C. Burnham (ORCID: https://orcid.org/0000-0003-4805-5193)
- Simon M. Laws (ORCID: https://orcid.org/0000-0002-4355-7082)
- John C. Morris
- Jason J. Hassenstab (ORCID: https://orcid.org/0000-0002-7802-3371)
- Michael S. W. Weiner
- Tenielle Porter
- Christopher C. Rowe
- Bhargav Tallapragada
Institutions
- Edith Cowan University (AU)
- Commonwealth Scientific and Industrial Research Organisation (AU)
- The University of Melbourne (AU)
- Eli Lilly (United States) (US)
- Murdoch University (AU)
- University of California, San Francisco (US)
- Washington University in St. Louis (US)
- Curtin University (AU)
- Florey Institute of Neuroscience and Mental Health (AU)
- Prevent Alzheimer’s Disease 2020 (US)
- Australian e-Health Research Centre (AU)
- CSIRO Health and Biosecurity (AU)
- Dementia Australia (AU)
- Austin Health (AU)
- Monash University (AU)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.090147
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00