Data‐driven Cognitive Composites and <i>APOE</i> ε4 Carriage Predict Progression to Mild Cognitive Impairment in Cognitively Unimpaired Older Adults

Together with APOE ε4 carriage, our PCA-derived domain-specific composites performed better than their summed z-score counterparts at predicting progression to MCI 15 years before symptom onset.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2024-12-01
DOI
https://doi.org/10.1002/alz.090147
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Data‐driven Cognitive Composites and APOE ε4 Carriage Predict Progression to Mild Cognitive Impairment in Cognitively Unimpaired Older Adults

Vincent Doré, James D. Doecke, Jürgen Fripp, Hamid R. Sohrabi et al.
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Data‐driven Cognitive Composites and APOE ε4 Carriage Predict Progression to Mild Cognitive Impairment in Cognitively Unimpaired Older Adults

Vincent Doré, James D. Doecke, Jürgen Fripp, Hamid R. Sohrabi, Yen Ying Lim, Colin L. Masters, Eleanor K. O’Brien, Liang Jin, Paul Maruff, Brook Galna, Rosita Shishegar, Belinda M. Brown, Shaun Markovic, Samantha C. Burnham, Simon M. Laws, John C. Morris, Jason J. Hassenstab, Michael S. W. Weiner, Tenielle Porter, Christopher C. Rowe, Bhargav Tallapragada
article en

Abstract

Together with APOE ε4 carriage, our PCA-derived domain-specific composites performed better than their summed z-score counterparts at predicting progression to MCI 15 years before symptom onset.

Alzheimer s & DementiaVol. 20(S3)
Edith Cowan University (AU), Commonwealth Scientific and Industrial Research Organisation (AU), The University of Melbourne (AU), Eli Lilly (United States) (US), Murdoch University (AU), University of California, San Francisco (US), Washington University in St. Louis (US), Curtin University (AU), Florey Institute of Neuroscience and Mental Health (AU), Prevent Alzheimer’s Disease 2020 (US), Australian e-Health Research Centre (AU), CSIRO Health and Biosecurity (AU), Dementia Australia (AU), Austin Health (AU), Monash University (AU)
Quality Education
Openalex Percentile: Top 66%
Dementia and Cognitive Impairment Research
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