Brain functional connectivity and neuropsychiatric symptoms in patients with mild cognitive impairment, cerebrovascular disease and Parkinson disease
This research underscores disorder-specific correlations between specific NPS domains and FC in MCI, CVD, and PD, emphasizing the unique neural underpinnings of symptomatology in each group. Furthermore, it is essential to note the inherent heterogeneity in all groups. Overall, the pathological substrates of neurodegenerative disorders likely play a pivotal role in shaping the neural correlates of MBI within each disorder. These findings provide valuable insights into targeted interventions and avenues for future research in neurodegenerative disorders.
Authors
- Anthony E. Lang (ORCID: https://orcid.org/0000-0003-1229-3667)
- Bruce G. Pollock (ORCID: https://orcid.org/0000-0003-0802-3998)
- Morris Freedman (ORCID: https://orcid.org/0000-0003-4003-6158)
- David F. Tang‐Wai (ORCID: https://orcid.org/0000-0001-9747-9967)
- Zahinoor Ismail (ORCID: https://orcid.org/0000-0002-5529-3731)
- Stephen C. Strother (ORCID: https://orcid.org/0000-0002-3198-217X)
- Robert Bartha (ORCID: https://orcid.org/0000-0002-7118-9096)
- Dallas Seitz (ORCID: https://orcid.org/0000-0003-1274-6451)
- Stephen Pasternak (ORCID: https://orcid.org/0000-0002-0204-0255)
- Melissa F. Holmes
- Maria Carmela Tartaglia (ORCID: https://orcid.org/0000-0002-5944-8497)
- Jennifer L. Mandzia (ORCID: https://orcid.org/0000-0002-1331-0695)
- Neda Rashidi‐Ranjbar (ORCID: https://orcid.org/0000-0002-2125-1090)
- Stephen R. Arnott (ORCID: https://orcid.org/0000-0002-0616-7771)
- Corinne E. Fischer (ORCID: https://orcid.org/0000-0002-1047-0167)
- Thomas Steeves
- Paula McLaughlin (ORCID: https://orcid.org/0000-0001-7173-8449)
- Nathan W. Churchill (ORCID: https://orcid.org/0000-0001-8481-2505)
- Tom A. Schweizer (ORCID: https://orcid.org/0000-0003-2278-3539)
- Sandra E. Black (ORCID: https://orcid.org/0000-0001-7093-8289)
- Dar Dowlatshahi (ORCID: https://orcid.org/0000-0003-1379-3612)
- David A. Grimes (ORCID: https://orcid.org/0000-0002-2115-1866)
- Miracle Ozzoude (ORCID: https://orcid.org/0000-0003-4154-2765)
- Sean Symons (ORCID: https://orcid.org/0000-0002-8025-9965)
- Joel Ramı́rez-Emiliano (ORCID: https://orcid.org/0000-0001-9813-9120)
- Andrew Frank (ORCID: https://orcid.org/0009-0002-8587-7727)
- Brian Tan (ORCID: https://orcid.org/0000-0002-6513-307X)
- Tarek K. Rajji (ORCID: https://orcid.org/0000-0002-8324-2560)
- Gustavo Saposnik (ORCID: https://orcid.org/0000-0002-5950-9886)
- Michael Borrie
- Connie Marras (ORCID: https://orcid.org/0000-0002-9236-9328)
- Courtney Berezuk (ORCID: https://orcid.org/0000-0001-6315-8815)
- Leanne K. Casaubon (ORCID: https://orcid.org/0000-0002-9792-1257)
- Christopher J.M. Scott (ORCID: https://orcid.org/0000-0002-3236-7523)
- David G. Munoz (ORCID: https://orcid.org/0000-0001-6027-8870)
- Sanjeev Kumar
- Mario Masellis
- Richard H. Swartz (ORCID: https://orcid.org/0000-0001-6571-5531)
Institutions
- Western University (CA)
- St. Michael's Hospital (CA)
- Sunnybrook Health Science Centre (CA)
- University Health Network (CA)
- Centre for Addiction and Mental Health (CA)
- University of Ottawa (CA)
- University of Calgary (CA)
- University of Toronto (CA)
- Heart and Stroke Foundation (CA)
- Toronto Western Hospital (CA)
- Hospital for Sick Children (CA)
- Health Sciences Centre (CA)
- Nova Scotia Health Authority (CA)
- Baycrest Hospital (CA)
- Toronto Dementia Research Alliance (CA)
- Parkwood Institute (CA)
- Robarts Clinical Trials (CA)
- Occupational Cancer Research Centre (CA)
- SickKids Foundation (CA)
- Bruyère (CA)
- Parkinson's Clinic of Eastern Toronto & Movement Disorders Centre (CA)
- Ontario Brain Institute (CA)
- Cognitive Research (United States) (US)
- Sunnybrook Hospital (CA)
- Krembil Brain Institute
- Sunnybrook Research Institute
- Hotchkiss Brain Institute (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087996
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00