Differentiating Sporadic behavioural variant Frontotemporal Dementia from late‐onset Primary Psychiatric Disorders: the DIPPA‐FTD study
Global cognition, letter fluency and attention scores, fronto-insula brain atrophy and NfL+GFAP have a significant role in discriminating sporadic bvFTD from PPD. Combination of markers can increase diagnostic accuracy in clinical setting. Promising markers identified in this retrospective study will be validated in the prospective DIPPA-FTD study and integrated in a data-driven approach to develop diagnostic and prognostic tools, enabling early-stage diagnosis sporadic bvFTD which is required for trial enrolment.
Authors
- Ishana Rue (ORCID: https://orcid.org/0000-0002-8954-1078)
- Ramón Landín-Romero (ORCID: https://orcid.org/0000-0003-0485-8090)
- Giorgio Fumagalli (ORCID: https://orcid.org/0000-0003-0687-7199)
- Zac Chatterton (ORCID: https://orcid.org/0000-0002-6683-1400)
- Glenda Margaret Halliday (ORCID: https://orcid.org/0000-0003-0422-8398)
- Olivier Piguet (ORCID: https://orcid.org/0000-0002-6696-1440)
- Sven J. van der Lee (ORCID: https://orcid.org/0000-0003-1606-8643)
- Lina Riedl (ORCID: https://orcid.org/0000-0002-0658-5332)
- Charlotte Elisabeth Teunissen (ORCID: https://orcid.org/0000-0002-4061-0837)
- Chiara Fenoglio (ORCID: https://orcid.org/0000-0001-6332-4721)
- Janine Diehl‐Schmid (ORCID: https://orcid.org/0000-0002-7745-1382)
- Daniela Galimberti (ORCID: https://orcid.org/0000-0002-9284-5953)
- Sterre C.M. de Boer (ORCID: https://orcid.org/0000-0002-9595-7221)
- Patrick Sommer (ORCID: https://orcid.org/0009-0005-2955-6461)
- Yolande A.L. Pijnenburg (ORCID: https://orcid.org/0000-0003-2464-1905)
- Timo Grimmer
- Simon Ducharme (ORCID: https://orcid.org/0000-0002-7309-1113)
- Sophie Matis
Institutions
- Montreal Neurological Institute and Hospital (CA)
- The University of Sydney (AU)
- University of Milan (IT)
- University of Trento (IT)
- Douglas Mental Health University Institute (CA)
- TUM Klinikum (DE)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Amsterdam Neuroscience (NL)
- Inn-Salzach-Klinikum (DE)
- Amsterdam University Medical Centers (NL)
- McGill University (CA)
- Technical University of Munich (DE)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.087999
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00