A spatial transcriptomics platform for characterizing cellular vulnerability and molecular changes in AD‐affected human brain tissue

Spatial methods are key to relating these neuronal vulnerabilities with pathological protein locations and specific locations within affected tissue. We have adapted spatial profiling and analysis methods to characterize the spatial relationships between specific neuronal types, amyloid plaques, tau tangles, and observed changes in gene expression. These data will offer novel insight into cell and molecular changes occurring at each phase of the disease and may inform the development of promising therapeutic interventions.