A human induced pluripotent stem cell model of Alzheimer’s Disease‐associated fractalkine receptor polymorphism to assess AD‐related microglial dysfunction
These findings suggest that the CX3CR1-V249I polymorphism may cause a dysfunctional microglia phenotype that may contribute to neuronal dysfunction and death. Ongoing work will expand upon the transcriptome and secretome profile of CX3CR1-V249I microglia and elucidate how this gene variant contributes to Alzheimer's Disease-related neurodegeneration.
Authors
- Kaylee D. Tutrow
- Shweta S. Puntambekar
- Jason S. Meyer (ORCID: https://orcid.org/0000-0001-9037-6033)
- Kang-Chieh Huang (ORCID: https://orcid.org/0000-0002-1538-2043)
- Bruce T. Lamb (ORCID: https://orcid.org/0000-0001-8507-2561)
- Jade Harkin (ORCID: https://orcid.org/0000-0003-0847-1352)
- Stephanie J. Bissel (ORCID: https://orcid.org/0000-0002-7376-2327)
- Melody Hernandez (ORCID: https://orcid.org/0000-0003-1338-1490)
Institutions
- University of Indianapolis (US)
- Neurosciences Institute (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089429
- Citations
- 2
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.49