Microglial deletion of C1q reduces phagocytosis of amyloid and synapses in an AD mouse model

Loss of microglial C1q reduces amyloid uptake by astrocyte and microglia and in the CA1 region, lack of microglial C1q also reduces Vglut1 association with the lysosomes in the Arctic AD mouse model.

Authors

Andrea J. Tenner (ORCID: https://orcid.org/0000-0003-3000-024X)
Shu‐Hui Chu (ORCID: https://orcid.org/0000-0003-3779-6412)
Tiffany J. Petrisko (ORCID: https://orcid.org/0000-0003-4664-2853)

Institutions

University of California, Irvine (US)

Publication Details

Journal: Alzheimer s & Dementia
Published: 2024-12-01
DOI: https://doi.org/10.1002/alz.086248
Primary Topic: Neuroinflammation and Neurodegeneration Mechanisms
Type: article
Field-Weighted Citation Impact: 0.00

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article

Microglial deletion of C1q reduces phagocytosis of amyloid and synapses in an AD mouse model

Andrea J. Tenner, Shu‐Hui Chu, Tiffany J. Petrisko

Dec 1, 2024

Alzheimer s & Dementia

Neuroinflammation and Neurodegeneration Mechanisms

article

Microglial deletion of C1q reduces phagocytosis of amyloid and synapses in an AD mouse model

Andrea J. Tenner, Shu‐Hui Chu, Tiffany J. Petrisko

December 1, 2024article en

Abstract

Loss of microglial C1q reduces amyloid uptake by astrocyte and microglia and in the CA1 region, lack of microglial C1q also reduces Vglut1 association with the lysosomes in the Arctic AD mouse model.

Alzheimer s & DementiaVol. 20(S1)

University of California, Irvine (US)

Life below water

Openalex Percentile: Top 72%

Neuroinflammation and Neurodegeneration Mechanisms

DOI Open Access PDF OpenAlex

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Microglial deletion of C1q reduces phagocytosis of amyloid and synapses in an AD mouse model — Andrea J. Tenner, Shu‐Hui Chu, et al. · Alzheimer s & Dementia (2024) | TGRS Research Map | TGRS