Leveraging a multi‐day learning paradigm to reveal early amyloid‐ and tau‐ related cognitive deficits in preclinical Alzheimer’s disease
Subtle differences in learning among CU older adults with different A/T biomarker profiles are observable using MDLCs. These findings further support the notion that a multi-day learning paradigm can provide unique information about cognition that is not captured using a single time-point assessment and is particularly relevant in preclinical AD.
Authors
- Roos J. Jutten (ORCID: https://orcid.org/0000-0002-3712-4790)
- Daniel Soberanes (ORCID: https://orcid.org/0000-0001-9099-7294)
- Gad A. Marshall (ORCID: https://orcid.org/0000-0002-9096-2355)
- Kathryn V. Papp (ORCID: https://orcid.org/0000-0003-1687-4370)
- Dorene M. Rentz (ORCID: https://orcid.org/0000-0002-6318-9213)
- Rebecca England Amariglio (ORCID: https://orcid.org/0009-0009-5878-8930)
- Stephanie Hsieh (ORCID: https://orcid.org/0000-0002-6929-6810)
- Keith A. Johnson (ORCID: https://orcid.org/0000-0002-5916-6043)
- Cassidy P. Molinare (ORCID: https://orcid.org/0009-0007-4969-7661)
- Michelle E. Farrell
- Reisa A Sperling
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.086313
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00