Exploring the relationship between neuropsychiatric symptoms, cognitive test performance, and brain abnormalities in a cohort of older adults in rural South Africa
NPI-Q symptoms were associated with lower cognitive performance, revealing a significant relationship between symptom severity and cognitive performance across all measures of the HAALSI-HCAP cognitive battery, except for those evaluating visuospatial function. Associations between neuropsychiatric symptoms and bilateral amygdala volume were less evident. These results contribute to understanding the impact of neuropsychiatric symptoms on cognitive health in aging South African populations.
Authors
- Sarah Gao (ORCID: https://orcid.org/0000-0001-5497-9638)
- Adam M. Brickman (ORCID: https://orcid.org/0000-0002-5125-8226)
- Stephen Tollman
- Darina T. Bassil (ORCID: https://orcid.org/0000-0002-2251-0613)
- Jennifer J. Manly (ORCID: https://orcid.org/0000-0002-9481-7497)
- Ryan G. Wagner (ORCID: https://orcid.org/0000-0003-2741-3676)
- Meagan T. Farrell (ORCID: https://orcid.org/0000-0002-4507-4017)
- Lisa Berkman
Institutions
- NewYork–Presbyterian Hospital (US)
- Harvard University (US)
- University of the Witwatersrand (ZA)
- New York Hospital Queens (US)
- IQVIA (United States) (US)
- Institute on Aging (US)
- Columbia University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092788
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00