P‐tau217 significance as marker of brain Abeta and tau pathologies
P-tau217 is a highly accurate marker of Abeta deposition. The strong association between p-tau217 and Abeta PET, when tau PET remains negative, supports tau hyperphosphorylation is a neuronal response to Abeta pathology independent from tau aggregation. On the other hand, p-tau217 associates with tau-PET at prodromal AD stage and occasionally changes in participants with primary tauopathies free of amyloid deposition. This corroborates soluble p-tau217 also increases because of the presence of brain tau aggregates. The duality of p-tau217 response to amyloid and tau pathology in AD complicates its utility as marker of tau aggregation. Lastly, plasma p-tau217 use as a single marker of Abeta positivity may expose to risk of false positive AD diagnosis for patients with primary tauopathies.
Authors
- Tammie L.S. Benzinger (ORCID: https://orcid.org/0000-0002-8114-0552)
- Lawren VandeVrede (ORCID: https://orcid.org/0000-0002-8304-6711)
- Richard J. Perrin (ORCID: https://orcid.org/0000-0002-3443-7716)
- Adam L. Boxer (ORCID: https://orcid.org/0000-0002-1215-5064)
- Audrey Gabelle (ORCID: https://orcid.org/0000-0002-7648-9194)
- Randall John Bateman (ORCID: https://orcid.org/0000-0002-7729-1702)
- Chihiro Sato (ORCID: https://orcid.org/0000-0002-7639-8727)
- Salvatore Spina (ORCID: https://orcid.org/0000-0003-3570-9143)
- Yingxin He (ORCID: https://orcid.org/0000-0003-2543-4553)
- Oskar Hansson (ORCID: https://orcid.org/0000-0001-8467-7286)
- Gemma Salvadó (ORCID: https://orcid.org/0000-0002-5210-9230)
- Eric McDade (ORCID: https://orcid.org/0000-0002-6764-3866)
- Nicolas R. Barthélemy (ORCID: https://orcid.org/0000-0003-4937-2860)
- Ross W. Paterson (ORCID: https://orcid.org/0000-0001-9372-3635)
- Suzanne E. Schindler (ORCID: https://orcid.org/0000-0002-1680-1465)
- Nupur Ghoshal (ORCID: https://orcid.org/0000-0002-6680-6731)
- Kanta Horie (ORCID: https://orcid.org/0000-0001-7736-2614)
- Brian A. Gordon (ORCID: https://orcid.org/0000-0003-2109-2955)
- Yan Li
- Soumya Mukherjee (ORCID: https://orcid.org/0000-0001-6852-508X)
- Shorena Janelidze
Institutions
- University of California, San Francisco (US)
- Lund University (SE)
- Washington University in St. Louis (US)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.089427
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00