Evaluation of the functional activity in synaptic genes related to polygenic risk for Alzheimer’s disease using a Massively Parallel Reporter Assay
All LD captured by the synaptic PRS contain SNPs that impact on regulatory activity, thus supporting a potential mechanism by which changes in the expression of these specific loci that encode synaptic proteins could lead to a modified cumulative risk for AD. Further studies to determine the precise mechanism involved in this regulatory activity at the synapse could guide future therapeutic strategies for AD.
Authors
- Érika Sánchez‐Aced (ORCID: https://orcid.org/0000-0001-7280-7493)
- Sònia Sirisi Dolcet
- Olivia Belbin (ORCID: https://orcid.org/0000-0002-6109-6371)
- Alberto Lleó (ORCID: https://orcid.org/0000-0002-2568-5478)
- Laia Muñoz (ORCID: https://orcid.org/0000-0003-0578-3094)
- Sara Serrano‐Requena
- Oriol Dols‐Icardo (ORCID: https://orcid.org/0000-0003-2656-8748)
- Alba Cervantes‐González
- Danna Perlaza
- Esther Álvarez‐Sánchez
- Natalia Valle Tamayo
- Laia Lidón Gil
- Joaquim Aumatell Escabias
Institutions
- Universitat Autònoma de Barcelona (ES)
- Hospital de Sant Pau (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Centro de Investigación Biomédica en Red (ES)
- Institut de Recerca Sant Pau (ES)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.090718
- Primary Topic
- Bioinformatics and Genomic Networks
- Type
- article
- Field-Weighted Citation Impact
- 0.00