Early hippocampal hyperexcitability precedes synaptic reorganization in mouse models of amyloidosis
These data indicate that elevated Aβ may initiate abnormal activity and subsequently input-specific synapse plasticity. Taken together, our findings indicate that sustained amyloidosis drives heterogeneous and progressive circuit-wide abnormalities.
Authors
- Ajit Ray (ORCID: https://orcid.org/0000-0003-2045-4109)
- Alison L. Barth (ORCID: https://orcid.org/0000-0001-7092-1356)
- Iulia Loghinov
Institutions
- Carnegie Mellon University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092939
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00