Circular RNA DENND1B contributes to cognitive impairment in Alzheimer’s disease by enhancing blood‐brain barrier permeability via transcellular regulatory axis

In conclusion, we demonstrated elevated circDENND1B levels in AD patients and provided evidence that the circDENND1B/lncRNA KCNQ1OT1/miR-17-5p/VegfA transcellular regulatory axis plays a role in regulating BBB permeability and neuron inflammatory response in both in vivo and in vitro AD models. This identified that circDENND1B/lncRNA KCNQ1OT1/miR-17-5p/VegfA transcellular regulatory axis may serve as a novel biomarker for AD, offering new insights for prediction, prognosis, and treatment of AD patients.