The loss‐of‐function variant in <i>MFSD3</i> could play a crucial role in the pathogenesis of dementia with Lewy bodies
Our results demonstrate that loss of function of MFSD3 affects neurons and the brain, as indicated by our studies using human neural stem cell lines and Mfsd3 KO mice. Further functional verification will contribute to elucidating the mechanism of DLB pathogenesis.
Authors
- Kazuhide Sawamura
- Nobuyoshi Shimoda (ORCID: https://orcid.org/0000-0003-0321-8905)
- Tohru Hosoyama (ORCID: https://orcid.org/0000-0002-1825-6923)
- Yuya Asanomi (ORCID: https://orcid.org/0000-0001-5326-4729)
- Daichi Shigemizu (ORCID: https://orcid.org/0000-0002-4412-0552)
- Kouichi Ozaki (ORCID: https://orcid.org/0000-0003-0028-1570)
- Noboru Ogiso (ORCID: https://orcid.org/0000-0003-3839-786X)
- Shumpei Niida (ORCID: https://orcid.org/0000-0002-6192-8035)
- Mutsumi Suganuma
- Tetsuaki Kimura (ORCID: https://orcid.org/0000-0002-2010-104X)
Institutions
- Hiroshima University (JP)
- RIKEN Center for Integrative Medical Sciences (JP)
- National Center for Geriatrics and Gerontology (JP)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.086694
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00