Exploring Protective Alleles in the Pathogenesis of Alzheimer’s Disease Using Mouse Models

We highlight that the primary mechanism of ABCA7 appears to be via the production of Ab and plaques. On the other hand, APOE Christchurch dramatically effects glial responses to pathology, notably increasing microglial reactivity to plaques, but markedly suppressing their response to tauopathy.

Authors

Kim N. Green (ORCID: https://orcid.org/0000-0002-6049-6744)

Publication Details

Journal: Alzheimer s & Dementia
Published: 2024-12-01
DOI: https://doi.org/10.1002/alz.087013
Primary Topic: Neuroinflammation and Neurodegeneration Mechanisms
Type: article
Field-Weighted Citation Impact: 0.00

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article

Exploring Protective Alleles in the Pathogenesis of Alzheimer’s Disease Using Mouse Models

Kim N. Green

Dec 1, 2024

Alzheimer s & Dementia

Neuroinflammation and Neurodegeneration Mechanisms

article

Exploring Protective Alleles in the Pathogenesis of Alzheimer’s Disease Using Mouse Models

Kim N. Green

December 1, 2024article en

Abstract

Alzheimer s & DementiaVol. 20(S1)

Good health and well-being

Openalex Percentile: Top 72%

Neuroinflammation and Neurodegeneration Mechanisms

DOI Open Access PDF OpenAlex

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Exploring Protective Alleles in the Pathogenesis of Alzheimer’s Disease Using Mouse Models — Kim N. Green · Alzheimer s & Dementia (2024) | TGRS Research Map | TGRS