Evaluating Congruence Between Clinical and Biological Staging Across The Alzheimer’s Disease Spectrum
Our findings highlight important discordance between clinical and biological stages, which could be partially explained by cognitive reserve. This was supported by the protective effects of educational attainment in participants with a higher biological stage. Vascular burden played a major role in the cognitive impairment of individuals with higher clinical stages. Future studies should replicate these findings in larger more representative population-based cohorts.
Authors
- Val J. Lowe (ORCID: https://orcid.org/0000-0002-5612-1667)
- Dana Tudorascu (ORCID: https://orcid.org/0000-0003-4675-3692)
- Tharick Ali Pascoal (ORCID: https://orcid.org/0000-0001-9057-8014)
- Cynthia Felix (ORCID: https://orcid.org/0000-0002-4283-4498)
- Guilherme Povala (ORCID: https://orcid.org/0000-0002-2023-6569)
- Douglas Teixeira Leffa (ORCID: https://orcid.org/0000-0002-4890-8451)
- Kaj Blennow (ORCID: https://orcid.org/0000-0002-1890-4193)
- Belén Pascual (ORCID: https://orcid.org/0000-0002-4467-7406)
- Carolina Soares (ORCID: https://orcid.org/0000-0002-2338-4495)
- William E. Klunk (ORCID: https://orcid.org/0000-0001-5512-0251)
- Guilherme Bauer‐Negrini (ORCID: https://orcid.org/0000-0003-0956-557X)
- Nesrine Rahmouni (ORCID: https://orcid.org/0009-0004-3081-8468)
- Pâmela C.L. Ferreira (ORCID: https://orcid.org/0000-0003-2134-9829)
- Emma Patrice Ruppert (ORCID: https://orcid.org/0000-0001-5877-5472)
- Matheus Scarpatto Rodrigues (ORCID: https://orcid.org/0000-0002-7794-6588)
- Thomas K. Karikari (ORCID: https://orcid.org/0000-0003-1422-4358)
- Bruna Bellaver (ORCID: https://orcid.org/0000-0002-2212-3373)
- William J. Jagust (ORCID: https://orcid.org/0000-0002-4458-113X)
- David N. Soleimani‐Meigooni (ORCID: https://orcid.org/0000-0003-4197-3039)
- Sarah Abbas
- Suzanne L. Baker (ORCID: https://orcid.org/0000-0003-0209-3127)
- Firoza Zubeida Lussier (ORCID: https://orcid.org/0000-0002-6877-4825)
- Cristiano Schaffer Aguzzoli (ORCID: https://orcid.org/0000-0002-7378-3830)
- Lívia Amaral (ORCID: https://orcid.org/0009-0005-4488-763X)
- Cécile Tissot (ORCID: https://orcid.org/0000-0003-2711-3833)
- Hussein Zalzale
- Brian A. Gordon (ORCID: https://orcid.org/0000-0003-2109-2955)
- Pedro Rosa‐Neto (ORCID: https://orcid.org/0000-0001-9116-1376)
- Pampa Saha (ORCID: https://orcid.org/0000-0002-4926-9081)
- Nicholas J. Ashton
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0002-4671-6763)
- Markley S. Oliveira
- Hwamee Oh (ORCID: https://orcid.org/0000-0003-1156-5704)
- Marina Scop Madeiros
Institutions
- Houston Methodist (US)
- Lawrence Berkeley National Laboratory (US)
- University of Pittsburgh (US)
- University of California, San Francisco (US)
- Washington University in St. Louis (US)
- Brown University (US)
- Instituto do Cérebro (BR)
- Mayo Clinic in Arizona (US)
- McGill University (CA)
- University of Gothenburg (SE)
- University of California, Berkeley (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.093241
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00