Neuropsychiatric symptoms and depression across cognitively‐defined AD subgroups at the time of AD diagnosis: data from the National Alzheimer’s Coordinating Center (NACC)

Composite scores for depressive and neuropsychiatric symptoms facilitate well-powered investigations of relationships with these clinically salient factors. Neuropsychiatric symptoms had trivial correlations with cognitive domain scores at AD dementia diagnosis, and did not differ across groups defined by substantial relative cognitive impairments. Depressive symptoms were weakly correlated with cognitive domain scores, and differed across groups defined by substantial relative cognitive impairments. More research is warranted to further characterize depression and neuropsychiatric symptoms over the course of AD dementia.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2024-12-01
DOI
https://doi.org/10.1002/alz.093240
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Neuropsychiatric symptoms and depression across cognitively‐defined AD subgroups at the time of AD diagnosis: data from the National Alzheimer’s Coordinating Center (NACC)

Taiki Sugimoto, Sarah Biber, Michael L. Lee, Emily H. Trittschuh et al.
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Neuropsychiatric symptoms and depression across cognitively‐defined AD subgroups at the time of AD diagnosis: data from the National Alzheimer’s Coordinating Center (NACC)

Taiki Sugimoto, Sarah Biber, Michael L. Lee, Emily H. Trittschuh, Andrew J. Saykin, Laura E. Gibbons, Paul K. Crane, Walter A. Kukull, Jeanne Gallée, Connie Nakano, Brandon S. Klinedinst, Phoebe Scollard, Shubhabrata Mukherjee, Jesse Mez, Seo‐Eun Choi
article en

Abstract

Composite scores for depressive and neuropsychiatric symptoms facilitate well-powered investigations of relationships with these clinically salient factors. Neuropsychiatric symptoms had trivial correlations with cognitive domain scores at AD dementia diagnosis, and did not differ across groups defined by substantial relative cognitive impairments. Depressive symptoms were weakly correlated with cognitive domain scores, and differed across groups defined by substantial relative cognitive impairments. More research is warranted to further characterize depression and neuropsychiatric symptoms over the course of AD dementia.

Alzheimer s & DementiaVol. 20(S3)
Boston University (US), University of Puget Sound (US), University of Washington (US), Geriatric Research Education and Clinical Center (US), Indiana University – Purdue University Indianapolis (US)
Openalex Percentile: Top 66%
Dementia and Cognitive Impairment Research
DOIOpen Access PDFOpenAlex
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Neuropsychiatric symptoms and depression across cognitively‐defined AD subgroups at the time of AD diagnosis: data from the National Alzheimer’s Coordinating Center (NACC) — Taiki Sugimoto, Sarah Biber, et al. · Alzheimer s & Dementia (2024) | TGRS Research Map | TGRS