Distinct associations of excitatory‐inhibitory (E/I) imbalance in aging and in Alzheimer’s disease
Our findings identified impaired inhibitory synaptic activity as the strongest correlate of neural circuit hyperexcitability in AD. In contrast, impaired timing of both excitatory and inhibitory neurons were the best predictors of neural circuit hyperexcitability in aging. These results suggest different mechanisms of neural circuit hyperexcitability in AD vs. aging and have important implications to translational as well as clinical studies probing early network changes.
Authors
- Ashish Raj (ORCID: https://orcid.org/0000-0003-2414-2444)
- Kiwamu Kudo (ORCID: https://orcid.org/0000-0002-5732-7229)
- Srikantan S. Nagarajan (ORCID: https://orcid.org/0000-0001-7209-3857)
- Heidi E. Kirsch (ORCID: https://orcid.org/0000-0002-3144-2085)
- Bruce L. Miller (ORCID: https://orcid.org/0000-0002-2152-4220)
- Parul Verma (ORCID: https://orcid.org/0000-0001-9956-4954)
- Kamalini G. Ranasinghe (ORCID: https://orcid.org/0000-0002-4217-8785)
- Gil Dan Rabinovici (ORCID: https://orcid.org/0000-0002-3626-4265)
- Keith Vossel
- Katherine P. Rankin (ORCID: https://orcid.org/0000-0002-3611-0848)
- Joel H. Kramer (ORCID: https://orcid.org/0000-0002-1206-404X)
- Faatimah Syed
Institutions
- University of California, Los Angeles (US)
- University of California, San Francisco (US)
- Ricoh (Japan) (JP)
- University Memory and Aging Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.091606
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00