Heterogenous Tau Pathology in the Hippocampus of Progressive Supranuclear Palsy
These findings support the view that hippocampal NFT pathology is not uncommon in PSP and may contribute to cognitive impairment in a subset of patients. Furthermore, the high variability in hippocampal NFTs nominates this region in PSP as a compelling brain area in which to assess correlations between tau accumulation and perturbations in neuronal cytoarchitecture.
Authors
- Merci N Best (ORCID: https://orcid.org/0000-0002-2602-8437)
- Ariel U. Spencer
- Paul M. Jenkins (ORCID: https://orcid.org/0000-0002-4207-5823)
- Emile Pinarbasi (ORCID: https://orcid.org/0000-0001-6313-483X)
- Henry L. Paulson (ORCID: https://orcid.org/0000-0002-0382-7535)
- Jonny Sexton
- J Lévy
- Vernon Carruthers
- Lia Min (ORCID: https://orcid.org/0000-0002-3977-1684)
- Einar Olafasson
Institutions
- University of Michigan (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1002/alz.092937
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00